IPG is a group of water soluble iron oxide nanoparticles with amphiphilic polymer coating conjugated to protein G. Their functional group is protein G. The zeta potential of SHS is from -20mV to -40mV. Their organic layers consist of a monolayer of oleic acid and a monolayer of amphiphilic polymer. The thickness of the total organic layers is about 4 nm. The hydrodynamic size of the nanoparticles is about 8-10 nm larger than their inorganic core size measured by TEM. The protein G molecules are covalently linked to the polymer. IPG is very stable in most buffer solutions.
IPG can bind to the Fc region of IgG thus present Ab in a directional manner for enhanced signal-to-noise ratio and reproducibility.
1. L. Yang, X. Peng, Y. A.Wang, X.Wang, Z. Cao, C. Ni, P. Karna, X. Zhang, W. C. Wood, X. Gao, S.Nie, H.Mao. Receptor-Targeted Nanoparticles for In vivo Imaging of Breast Cancer
. Clinical Cancer Research, 2009, 15, 4722-4732.
|SHP||Iron oxide nanoparticles with carboxylic acid||5-30 nm|
|SYP||Lyophilized (Lyof™) iron oxide nanoparticles with carboxylic acid||5-30 nm|
|SVP||Autoclaved (AclaFTM) iron oxide nanoparticles with carboxylic acid||5-30 nm|
|SHA||Iron oxide nanoparticles with amine||5-30 nm|
|ICK||Carboxyl terminated iron oxide nanoparticles with various diameters (10 nm-30 nm).||10-30 nm|
|SHP-COMBO||A group of 3 or 5 different iron oxide nanoparticles with carboxylic acid||10-30 nm|
|SEI||Iron oxide nanoparticles with positively charged PEI surface||10-30 nm|
|SMG||Iron oxide nanoparticles with PEG ||10-30 nm|
|IRB||Iron oxide nanoparticles with Rhodamine B||10 nm|
|IPG||Iron oxide nanoparticles with Protein G||10-30 nm|
|ILA||Lipid coated iron oxide nanoparticles with amine ||10-30 nm|