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SHS is a group of water soluble iron oxide nanoparticles with amphiphilic polymer coating conjugated to streptavidin. Their functional group is streptavidin. The zeta potential of SHS is from -20mV to -40mV. Their organic layers consist of a monolayer of oleic acid and a monolayer of amphiphilic polymer. The thickness of the total organic layers is about 4 nm. The hydrodynamic size of the nanoparticles is about 8-10 nm larger than their inorganic core size measured by TEM. The streptavidin molecules are covalently linked to the polymer. SHS is very stable in most buffer solutions.
SHS can capture biotinylated molecules such as protein, DNA and peptide. For the reactions to link biotinylated molecules onto SHS, it is necessary to use monobiotinylated molecules, which have only one biotin linked to each biomolecule. Otherwise, the nanoparticles will aggregate.
Catalog No.SizeAmount(Fe weight)Particle Amount(nmole) of 1 mg FePrice($) 
SHS-05-015 nm1 mg6.9399.00
SHS-05-055 nm5 mg6.9999.00
SHS-10-0110 nm1 mg0.86199.00
SHS-10-0510 nm5 mg0.86799.00
SHS-15-0115 nm1 mg0.27199.00
SHS-15-0515 nm5 mg0.27799.00
SHS-20-0120 nm1 mg0.11199.00
SHS-20-0520 nm5 mg0.11799.00
SHS-25-0125 nm1 mg0.058199.00
SHS-25-0525 nm5 mg0.058799.00
SHS-30-0130 nm1 mg0.034199.00
SHS-30-0530 nm5 mg0.034799.00
References:
1. L. Yang, X. Peng, Y. A.Wang, X.Wang, Z. Cao, C. Ni, P. Karna, X. Zhang, W. C. Wood, X. Gao, S.Nie, H.Mao. Receptor-Targeted Nanoparticles for In vivo Imaging of Breast Cancer. Clinical Cancer Research, 2009, 15, 4722-4732.
2. L. Yang, H. Mao, Z. Cao Y. A. Wang, X. Peng, X. Wang, H.K. Sajja, L.Wang, H.Duan, C. Ni, C. A Staley, W. C. Wood, X. Gao, S. Nie. Molecular Imaging of Pancreatic Cancer in a Preclinical Animal Tumor Model Using Targeted Multifunctional Nanoparticles. Gastroenterlogy, 2009, 136, 1514-1525.
3. L. Yang, H. Mao, Y. A. Wang, Z. Cao, X. Peng, X. Wang, H. Duan, C. Ni, Q. Yuan, G. Adams, M. Q. Smith, W. C. Wood, X. Gao, S. Nie. Single Chain Epidermal Growth Factor Receptor Antibody Conjugated Nanoparticles for in vivo Tumor Targeting and Imaging. Small, 2009, 5, 235-243.
4. J. Yang, J.Gunn, S. Dave, M.Zhang, Y. A Wang, X. Gao. Ultrasensitive Detection and Molecular Imaging with Magnetic Nanoparticles. The Analysis, 2008, 133, 154–160.
5. H. Duan, M. Kuang, X. Wang, Y. A. Wang, S. Nie, H Mao. Reexamining the effects of particle size and surface chemistry on magnetic properties of iron oxide nanocrystals: new insights into spin disorder and proton relaxivity. The Journal of Physical Chemistry C, 2008, 112, 8127–8131.
6. X. Peng, X Qian, H Mao, YA Wang, Z Chen, S Nie, DM Shin. Targeted magnetic iron oxide nanoparticles for tumor imaging and therapy. International Journal of Nanomedicine, 2008, 3, 311-321.
7. L. Yang, Z. Cao, H. K. Sajja, H. Mao, L. Wang, H. Geng, H. Xu, T. Jiang, W. C. Wood, S. Nie, Y. A. Wang. Development of Receptor Targeted Magnetic Iron Oxide Nanoparticles for Efficient Drug Delivery and Tumor Imaging. Journal of Biomedical Nanotechnology, 2008, 4, 439-449.
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